WebRobo proteins are a class of transmembrane receptor proteins with 1000 to 1600 amino acids and have highly conserved intracellular domains with no autocatalytic or intrinsic enzymatic activity. http://www.cancerindex.org/geneweb/ROBO1.htm
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WebOverexpression of wild-type ROBO1 and the ROBO1 R77H mutant (a,c), as well as wild-type ROBO2 and the ROBO2 G107E mutant (b,d), induced an increase in apoptosis in K562 (a,b) and HEL (c,d) cells. WebThe Roundabout (Robo) receptors, located on growth cones of neurons, induce axon repulsion in response to the extracellular ligand Slit. The Robo family of proteins controls …
WebNov 10, 2024 · ROBO1 is expressed in both luminal and basal cells, but loss of Robo1 in basal cells results in the luminal differentiation defect. In the basal compartment, ROBO1 inhibits the expression of Notch ligand Jag1 by regulating β-catenin (CTNNB1), which binds the Jag1 promoter. WebROBO1 Overexpression Lysate. Tested Reactivity: Hu. Validated: WB. Backed by our 100% Guarantee. Skip to main content Support: 1-888-506-6887 Items in Cart (0) [X] Quick Order …
WebJan 24, 2024 · In this study, upregulated expression of circROBO1 was found in BC-derived liver metastases and was correlated with poor prognosis. Knockdown of circROBO1 strikingly inhibited the proliferation, migration, and invasion of BC cells, whereas overexpression of circROBO1 showed the opposite effects. WebAug 29, 2024 · After transfection with ROBO1-specific siRNA, the expression of ROBO1 was decreased with fold-change of 0.30 ± 0.08, indicating successful transfection. Similar to the effect of miR-218 overexpression, silencing of ROBO1 reduced DKK1 secretion from RA-FLS (Fig. 5c). These results suggest that miR-218 promote osteogenic differentiation of RA ...
WebThe results were assessed by Kaplan-Meier analysis and log-rank test. Results: The positive expression rate of Robo1 among adjacent non-cancerous tissues, lung cancers tissues …
WebMar 13, 2024 · Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a group 1 carcinogen that introduces mutagenic DNA adducts into the genome. In this study, we investigated the molecular mechanisms underlying the involvement of silymarin in the reduction of DNA adduct formation by B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE), induced … brian may harley benton bm-75 guitarWeb1 day ago · 3 pts had stable disease (1 with EGFR overexpression and gene CNA; 2 not evaluable for IHC), with tumor reductions of 2%, 17%, and 40%. Petosemtamab continues to demonstrate a manageable safety ... courthouse miramichi nbWebJul 14, 2024 · In conclusion, SLIT2 overexpression in periodontitis intensifies inflammation, immune cells infiltration, M1 macrophage polarization, osteoclastogenesis, and alveolar bone loss, possibly via activation of MAPK signaling, suggesting the role of SLIT2 on exacerbation of periodontitis and alveolar bone loss. Introduction brian may heart issues 2021WebThe ROBO1 gene is located on chromosome 3p12.3 and consists of 35 exons. It encodes an integral membrane protein that is a member of the immunoglobulin gene superfamily. … courthouse midland texasWebApr 9, 2015 · PD-L1 overexpression is not the oncogenic driver of the tumor, but rather a co-opted and maladaptive immune shield that protects the tumor from its immune … brian mayhew ncdotWebObjective: To detect the expression of Robo1 in different breast tumors and its association with the breast cancer brain metastasis. Methods: Labelled streptavidin-biotin (LSAB) … brian mayhew photographyWebSep 16, 2012 · For Robo1 overexpression, Lenti-X bicistronic lentiviral vector expression system (Clontech) was used according to the manufacture's instruction. Mouse tumorigenicity assay Animal experimental protocols were approved by the Institutional Animal Care and Utilization Committee, Academia Sinica. brian may guitars.com