Gwas hcc
WebJan 24, 2011 · Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the two major forms of primary liver cancers (PLC), accounting for approximately 90% and 5% respectively. The incidence of each is increasing rapidly in the western world, however our knowledge of the underlying mechanisms remains limited and the outcome, … WebMar 31, 2016 · In the discovery phase using a meta-analysis of the GWAS results from the two cohorts, Sydney MAS and OATS, twelve genome-wide significant SNPs were observed (p < 5 × 10 −8) when age, sex and ...
Gwas hcc
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WebFeb 1, 2024 · A GWAS demonstrated that patients with HCV-related HCC had a higher rate of the MICA rs2596542 A allele (Kumar et al., 2011). The evidence was based on cross-sectional observations. However, whether genetic predisposition increased the long-term risk of HCC development is unclear. WebThe primary GWAS data set was extracted from our previous study. 15 Clinicopathological characteristics and prognosis of the HBV-related HCC patients, genotyping, quality control, and GWAS analysis methods have been described and published in our earlier article. 15 A total of 403 patients with serum tests that were HBV surface antigen positive ...
WebSep 14, 2012 · Through a GWAS using a total of 5,892 cases and 17,809 controls, we identified three novel nephrolithiasis loci: rs11746443, rs1000597, and rs4142110 (P<1×10−8).
WebMay 11, 2024 · Due to small effect size, no variants in the discovery GWAS sample of 1307 HBV-related HCC cases and 1574 controls had a p-value less than the widely-adopted genome-wide cutoff (5E-8). It was the gene-based association analysis combing the p-values of multiple SNPs that achieved genome-wide significant p-values at some genes. … WebThe Township of Fawn Creek is located in Montgomery County, Kansas, United States. The place is catalogued as Civil by the U.S. Board on Geographic Names and its …
WebTelomerase reverse transcriptase (TERT) promotes immortalization by protecting telomeres in cancer cells.Mutation of the TERT promoter is one of the most common genetic alterations in hepatocellular carcinoma (HCC), indicating that TERT upregulation is a critical event in hepatocarcinogenesis. Regulators of TERT transcription are, therefore, …
WebTagSNPs associated with HBV-related HCC risk were ob-tained from GWASs of HBV-related HCC which were re-trieved in the GWAS Catalog and PubMed up to April 30, … score for yankees todayWebChi-Kwan Leung, ... Zi-Jiang Chen, in The Ovary (Third Edition), 2024. Abstract. Genome-wide association study (GWAS) has revolutionized the identification of causal genetic variants and the subsequent characterization of complex genetic traits. GWAS is a powerful approach to survey casual variants with a modest contribution to the overall trait … score for yankees game todayWebFeb 3, 2024 · We found a strong association between the SNP rs17047200, located within the intron of the tolloid like 1 gene (TLL1) on chromosome 4, and development of HCC; there was a genome-wide level of significance when the results of the GWAS and replication study were combined (odds ratio, 2.37; P = 2.66 × 10 −8).Multivariate analysis showed … score for yankeesWebThis GWAS of HCC relied on existing biological and data resources from 7 USA sites and one Canadian site which allows for the integration of genetic and environmental data. Total of 2199 case patients and 1103 non cancer controls were genotyped. Case patients are defined as patients with pathological or radiological diagnosis of HCC with and ... predicted electron configurationWebJan 11, 2024 · Therein, the association of rs2275959 with HBV-related HCC had been identified by previous GWAS (Chan et al., 2011), and there was an association between rs2275959 and survival time of HBV-related HCC patients (Hazard ratio = 1.22, p = 3.51 × 10 −2), indicating rs2275959 could be considered good prognostic candidates for HCC … predicted electricity price risesWebAug 26, 2024 · Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants across many genomes to find those statistically associated with a specific trait or disease. This methodology ... score fred taylor rookieWebFeb 11, 2024 · The genome-wide association study (GWAS) is an effective method to detect single-nucleotide polymorphisms (SNPs) of multiple individual genes based on linkage disequilibrium (LD). GWAS examines genotypes and distinguishing gene characteristics that are exhibited in diseases. ... (HCC) is one of the most common malignancies in China … predicted end of covid 19