WebOct 15, 2012 · Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a signaling mechanism that allows cellular adaptation to ER stress by engaging pro-adaptive transcription factors and alleviating protein folding demand. One such transcription factor, X-box binding protein (XBP1), originates from the inositol-requiring … WebSep 28, 2012 · Primordial germ cells (PGCs) sequentially induce specific genes required for their development. We focused on epigenetic changes that regulate PGC-specific gene expression. mil-1, Blimp1, and Stella are preferentially expressed in PGCs, and their expression is upregulated during PGC differentiation. Here, we first determined DNA …
Conserved and Unique Functions of Blimp1 in Immune Cells
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Conserved and Unique Functions of Blimp1 in Immune Cells
WebMW performed most experiments, TP performed the flow-cytometric analyses of unimmunized PCs, the intracellular staining of IgM expression and the Blimp1 rescue experiments, PB performed the Xbp1 ChIP-seq experiment, AH and JS performed the glycosylation analysis, DK-P generated the Xbp1 Bio/+ mouse, SK generated the … WebOct 30, 2024 · In mammals, Blimp1 (B lymphocyte-induced maturation protein 1) encoded by the prdm1 gene and its homolog Hobit (homolog of Blimp1 in T cells) encoded by znf683, represent key transcriptional … WebFeb 12, 2024 · Blimp1 negatively regulates IL-6- and STAT3-dependent Dnmt3a … biots pronunciation